ESPE Yearbook of Paediatric Endocrinology

J Clin Endocrinol Metab. 2020;105(10):dgaa440. 10.1210/clinem/dgaa440 https://academic.oup.com/jcem/article/105/10/3134/5868100In brief: Based on a 20-year Danish registry, this study reports a marked increase in incidence of gynecomastia between 1998 to 2017, 5-fold among post-pubertal males age 16–20 years, and ...

To read the full abstract: J Clin Endocrinol Metab. 2018 Jan 1;103(1):228-234[Comments on 7.5 and 7.6] Remarkably, the timing of puberty shows important differences between individuals1. Based on twin studies, differences in pubertal timing are considered to depend on genetic factors which account for up to 60-70% of the varianc...

JAMA Netw Open. 2020;3(10):e2015665. 10.1001/jamanetworkopen.2020.15665.. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2771377In brief: This Danish population-based 20-year cohort study provides strong epidemiological data supporting substantial increases in central precocious pub...

To read the full abstract: JAMA Pediatr. 2020;174(4):e195881. doi: 10.1001/jamapediatrics.2019.5881• The authors evaluated the change in pubertal onset in healthy girls around the world based on age at thelarche.• Overall, the age at thelarche decreased 0.24 years per decade from 1977 to 2013.• This decrease seems to reflect a worldwide trend....

Brief summary: This long-term longitudinal study of 437 Danish girls shows that AMH level measured in infancy is a useful tool to predict future ovarian activity.Anti-Müllerian hormone (AMH) is produced by granulosa cells in small ovarian follicles and thus reflects the ovarian reserve of resting primordial follicles (1). High AMH concentrations are observed in women with polycystic ovarian syndrome (PCOS) (2), while low age-specific AMH could be as...

To read the full abstract: Nature communications vol. 11,1 1536. 24 Mar. 2020. doi: https://www.nature.com/articles/s41467-020-14451-5This multi-trait genome-wide association study (GWAS) for male puberty timing identifies 76 independent signals for puberty timing and highlights relationships with natural hair colour and lifespan. The timing of puber...

To read the full abstract: Science 2019;365:eaat7693.These authors performed a genome-wide association study on 493 001 participants of European-ancestry from the USA, UK, and Sweden to identify genes associated with sexual orientation. They found multiple loci implicated in same-sex sexual behavior indicating that, like other behavioral traits, non-heterosexual behavior is polygenic.As many as 4% to 10% of US individuals ...

To read the full abstract: J Clin Endocrinol Metab. 2020, Mar 1; 105. doi: https://academic.oup.com/jcem/article-abstract/105/3/e222/5609091?redirectedFrom=fulltextThis cross-sectional study collected measures of genital development from 181 premature neonates, 378 term neonates, 308 babies up to 24 months, and in 111 babies with atypical geni...